An attempt at replicating a few analyses from this paper (https://www.nature.com/articles/s41586-021-03569-1#Sec44)
Due to restrictions on computing power and memory, only two samples (C56ctr, L01cov) were analysed. Therefore, the results mentioned here would not be the same mentioned in the paper.
- leiden_umap_1.png shows the corresponding group assignments of the cells in the UMAP.
- "C56ctr" is the control sample while "L01cov" is the sample from a patient with COVID19.
- leiden_umap_2.png shows the subpopulation assignments with numbers.
- leiden_umap_2.png shows the subgroups of cells present in the samples.
- heatmap.png shows the differentially expressed genes between the control and the COVID19 sample. Genes like LAMA3 and PARD3 were found to be highly expressed in the sample with COVID19