Description

GPSW is a tool for analysing Global Protein Stability Profiling data.

It can deal with two types of experiments:

1. Protein stability profiling using Protein Stability Index (PSI) as a metric, which is calculated from the proportion of reads across multiple bins. Publications that include this type of data are Koren et al. Cell 2018 and Timms et al. Science 2019.

2. Pairwise comparison of ORF counts between two conditions using MAGeCK/DrugZ

Documentation

Documentation is available here.

Post-analysis scripts

We are also developing post-analysis scripts to further analyse the output of GPSW or to prepare publication quality figures. These scripts are available in a separate repository: gps-orfeome-tools.