Cornelis + Mike and friends
December 2020
Goal: Test whether there are genetic differences between males and females with PD... Main reason for testing this is that males are ~1.5x more likely to develop PD.
Link to manuscript here
Link to publication here (coming soon)
IPDGC_data.md => Data processing and GWAS of the IPDGC data
UKBiobank_data.md => Data processing and GWAS of the UK Biobank data
Meta analyses of Results.md => Meta-analyses of the IPDGC data and UK Biobank data
Additional analyses.md => Additional analyses performed including assessment of genetic risk score and LDSCORE regression
| DATASET | male_case | male_control | female_case | female_control |
|---|---|---|---|---|
| DUTCH | 486 | 877 | 279 | 1105 |
| FINLAND | 209 | 104 | 177 | 388 |
| GERMANY | 436 | 490 | 276 | 452 |
| HBS | 346 | 181 | 181 | 291 |
| MCGILL | 379 | 467 | 201 | 438 |
| MF | 439 | 307 | 311 | 470 |
| NEUROX_DBGAP | 3491 | 3232 | 1914 | 2572 |
| NIA | 500 | 1420 | 341 | 1581 |
| OSLO | 306 | 267 | 170 | 195 |
| PDBP | 314 | 138 | 198 | 142 |
| PPMI | 243 | 110 | 120 | 55 |
| SHULMAN | 508 | 59 | 260 | 136 |
| SPAIN3 | 1198 | 608 | 910 | 723 |
| SPAIN4 | 1349 | 739 | 1010 | 814 |
| TUBI | 421 | 227 | 237 | 307 |
| UK_GWAS | 982 | 2626 | 627 | 2569 |
| VANCE | 447 | 147 | 172 | 151 |
| UKBIO_case | 966 | 7337 | 563 | 7941 |
| SUM (all case-control) | 13020 | 19336 | 7947 | 20330 |
| UKBIO_proxy | 7936 | 70324 | 5473 | 70332 |
| SUM (all) | 20956 | 89660 | 13420 | 90662 |
| TOTAL included | 110616 | XX | 104082 | XX |