Graphic mark of "AOP-networkFinder. Green represent Molecular Initiation Events (MIEs) in the Adverse Outcome Pathway (AOP). Orange represents adherent Key Events (KEs). Red triangles represent Adverse Outcomes (AOs), at the end of the path. The arrows illustrate the direction of Key Events Relationships (KERs). Blue circles represent genes connected to KEs. Notice that this representation is in form a Directed Acyclic Graph (DAG) with no directed cycles.

Web-Application AOP-networkFinder is available under:

https://aop-networkfinder.no/

Please cite the AOP-networkFinder: BIORXIV/2024/591733 "AOP-networkFinder - A versatile and user-friendly tool for FAIR reconstruction of Adverse Outcome Pathway networks from the AOP-Wiki" Authors: Nurettin Yarar, Marvin Martens, Torbjørn Rognes, Jan Lavender, Hubert Dirven, Karine Audouze and Marcin W. Wojewodzic#

Corresponding author: Marcin W. Wojewodzic (Email: maww [at] fhi.no)

Tool version v1 is also on Zenono at Computational Toxicology at Norwegian Institute of Public Health: https://zenodo.org/records/11068434

1. Finds the status of all AOPs in the webpage AOPWiki.org/aops (OECD Status)

The Current GUI of the AOP_Visualizer webpage:

2. How to run the application locally using Docker

Prerequisites

Docker installed on your system.

Building the Docker Image

To build the Docker image, use the following command:

docker build --platform=linux/amd64 -t aop-networkfinder:v1 .

3. Running the Application

To run the Docker Container:

docker run --platform=linux/amd64 -d -p 8000:8000 -e aop-networkfinder:v1

To access the application locally: http://localhost:8000

You should see a window similar to this: