mind-metab-sharing

Code repository for the project 'Circulating metabolomic profile of the MIND diet and its relation to cognition in middle-aged and older adults'.

Descriptions

This code repository documents the code scripts for the project 'Circulating metabolomic profile of the MIND diet and its relation to cognition in middle-aged and older adults'.

Dataset required for analysis

• UK Biobank: Data are available on request from https://www.ukbiobank.ac.uk.

• Whitehall II: Data are available on request for bone fide investigators from https://www.ucl.ac.uk/epidemiology-health-care/research/epidemiology-and-public-health/research/whitehall-ii.

File structure

• /Analysis: Code scripts for data analysis

  • readin.R: Read in datasets

  • mind-mb.R: Associations between aMIND and metabolites

  • mind-mets.R: Construction of the MIND-MetS

  • mediation.R: Mediation on cognitive function (WHII) and dementia (UKB)

• /Supplementary Tables.xlsx: Meta data for figure repruduction of figures

• /Figures: Code scripts for data visulization

  • Figure 1

    • Fig1B.R: Associations between aMIND and metabolites

    • Fig1C.R: Associations between food groups and metabolites

  • Figure 2

    • Fig2A.R: Weight shrinkage in the elastic net

    • Fig2B.R: Weights of metabolites in the elastic net model

    • Fig2CDE.R: Correlations between aMIND and MIND-MetS in the UKB-Training, UKB-Validation, and WHII.

Citation

Please cite this paper with:

Chen, H.; Shen, J.; Tao, Y.; et al. Circulating metabolomic profile of the MIND diet and its relation to cognition in middle-aged and older adults. iMetaOmics. in press