Explore the therapeutic applications of pooled and arrayed CRISPR screens
Wellcome Connecting Science Course Website
Course is comprised of two parts and attendance is mandatory to complete the course:
- A 5-day hands-on virtual component (28 July – 1 August 2025) covering genome informatics, computational design and analysis
- A 5-day in-person component (21-26 September) with laboratory and informatics practicals and workshops focused on pooled and arrayed screening
Pooled and arrayed CRISPR screens have diverse clinical and research applications. Arrayed screening involves targeted gene editing for investigating specific gene function and biological pathways, whereas pooled screening enables a rapid high-throughput global approach to gene discovery.
The programme will be delivered as a combination of lectures, interactive tutorials, hands-on laboratory and computer practical sessions, workshops, and seminars focused on three therapeutic areas where pooled and arrayed screens are used, namely:
- Oncology
- Neurodegeneration
- Immunology
Additionally, for each component of the course, a group project will be completed to aid in achievement of the learning objectives.
The course content will be delivered in English.
Applicants should be postdoctoral scientists, advanced PhD students actively engaged in or soon to commence relevant research. It is also suitable for facility managers and principal investigators wishing to bring the latest genetic technologies into their facilities or groups.
Upon completion of this course, participants should be able to:
- Design and execute CRISPR based genetic screening approaches in both pooled and arrayed formats
- Understand CRISPR-based genetic screening methods, including design, reagents, and techniques including their advantages and limitations
- Perform CRISPR screening analysis using available tools and resources
Course Instructors
- Matthew Coelho, Wellcome Sanger Institute, UK
- Kalpana Surendranath, University of Westminster, UK
- Andrew Bassett, Wellcome Sanger Institute, UK
- Panos Zalmas, Open Targets, UK
- Sunay Usluer, Wellcome Sanger Institute, UK
- Jamie Billington, Wellcome Sanger Institute, UK
- Cansu Dinser, Wellcome Sanger Institute, UK
- Sandeep Sundara Rajan, Wellcome Sanger Institute, UK
- Khalid Akram, University of Westminster, UK
- Helena Cornu, EMBL-EBI, Open Targets, United Kingdom
- Saamin Cheema, Wellcome Sanger Institute, UK
- Munuse Savash, Nuffield Department of Women’s and Reproductive Health, UK
- Nithila Joseph, Wellcome Sanger Institute, UK
- Stuart Horswell,Wellcome Sanger Institute, Open Targets, UK
- Saroor Patel, Wellcome Sanger Institute, UK
- Salman Tamaddon-Jahromi,Wellcome Sanger Institute, Open Targets, UK
- Suruchi Pacharne, Wellcome Sanger Institute, Open Targets, UK
Wellcome Connecting Science Team
- Cassandra Soo, Laboratory Courses Manager
- Aaron Dean, Laboratory Technical Officer
- Amy Pass, Events Organiser
- Martin Aslett, Informatics Manager
- Vaishnavi Vikas Gangadhar, Informatics Technical Officer
- Alice Matimba, Head of Training and Global Capacity
The course data are free to reuse and adapt with appropriate attribution. All course data in these repositories are licensed under the Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0).
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