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SPP1-Macrophages

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Ruben Bill et al. ,CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers.Science381,515-524(2023).DOI:10.1126/science.ade2292

干湿:Qi J, Sun H, Zhang Y, Wang Z, Xun Z, Li Z, Ding X, Bao R, Hong L, Jia W, Fang F, Liu H, Chen L, Zhong J, Zou D, Liu L, Han L, Ginhoux F, Liu Y, Ye Y, Su B. Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer. Nat Commun. 2022 Apr 1;13(1):1742. doi: 10.1038/s41467-022-29366-6

Su, Z., He, Y., You, L. et al. SPP1+ macrophages and FAP+ fibroblasts promote the progression of pMMR gastric cancer. Sci Rep 14, 26221 (2024). https://doi.org/10.1038/s41598-024-76298-w

Tang, W., Lo, C.W.S., Ma, W. et al. Revealing the role of SPP1+ macrophages in glioma prognosis and therapeutic targeting by investigating tumor-associated macrophage landscape in grade 2 and 3 gliomas. Cell Biosci 14, 37 (2024). https://doi.org/10.1186/s13578-024-01218-4

Cha, S.M., Park, JW., Lee, Y.J. et al. SPP1+ macrophages in HR+ breast cancer are associated with tumor-infiltrating lymphocytes. npj Breast Cancer 10, 83 (2024). https://doi.org/10.1038/s41523-024-00695-7

干湿:Liu, C., Wu, K., Li, C. et al. SPP1+ macrophages promote head and neck squamous cell carcinoma progression by secreting TNF-α and IL-1β. J Exp Clin Cancer Res 43, 332 (2024). https://doi.org/10.1186/s13046-024-03255-w

干湿:Wang Y, Wang Q, Tao S, Li H, Zhang X, Xia Y, Wang Y, Yang C, Sui C. Identification of SPP1+ macrophages in promoting cancer stemness via vitronectin and CCL15 signals crosstalk in liver cancer. Cancer Lett. 2024 Nov 1;604:217199. doi: 10.1016/j.canlet.2024.217199

markers:

cell types markers
Macrophage CD68,LGMN, CTSB
SLC40A1+ macrophage CD68,LGMN, CTSB, SLC40A1, TGFB1, CCL18
SPP1+ macrophage CD68,LGMN, CTSB, SPP1, TNF, IL1A
mast cells TPSAB1
NK/T cells CD3E
epithelial cells EPCAM
B cells CD19
endothelial cells PECAM1
neutrophils NCF1
smooth muscle cells ACTA2
myeloid cells CD68
fibroblasts COL1A1
plasma cells MZB1

SPP1-CD44 axis

SPP1:secreted phosphoprotein 1, osteopontin

CD44:cell-surface glycoprotein

SPP1-CD44 signaling promotes tumor stemness, chemoresistance, and creates an immunosuppressive microenvironment by modulating T cell function and macrophage polarization

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