Health-Care-Interoperability-project

The Fibrillin Genies Interoperability Project

INFO‑B‑581: Health Informatics Standards and Terminology
Professor: Saptarshi Purkayastha
**PS1–PS4 (Project Sprints 1–4)
Group 6: The Fibrillin Genies

• Hemanth Sai Kumar Gaddam
• Puja Darshana Mishra
• Priyanka Kuta Reddy
• Sanjana Rajan

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📖 Table of Contents

1. Project Overview
2. Sprint 1: Use Case Selection
3. Sprint 2: Problem Analysis & Modelling
4. Sprint 3: CDA Implementation
5. Sprint 4: XSLT‑Driven Interoperability
6. Repo Structure
7. Getting Started
8. Cloning Our GitHub Repo
9. References

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📝 Project Overview

We demonstrate end‑to‑end interoperability for a genetic testing use case: a 34‑year‑old male with pectus excavatum, long fingers, flat feet, and joint hypermobility is referred for FBN1 genetic testing. The lab identifies the c.7039_7040del (p.Met2347fs) variant. Results flow back to the clinician for diagnosis.

We cover four sprints:

1. Use Case Selection
2. Problem Analysis & Modelling
3. CDA Document Creation & Viewing
4. XSLT‑Based Data Transformation

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🚀 Sprint 1: Use Case Selection

• Team Name: The Fibrillin Genies

• Course: INFO‑B‑581 (Health Informatics Standards & Terminology)

• Use Case:

  A 34‑year‑old male with a history of rib cage defect (Pectus excavatum), long fingers, flat feet, and double‑jointedness. Clinician orders FBN1 genetic testing → Lab finds c.7039_7040del positive → Results returned → Diagnosis made.

• Standards & Terminologies Chosen:

  • SNOMED CT for clinical findings
  • ICD‑10 for diagnoses
  • HPO for phenotypic terms
  • LOINC for laboratory/genetic tests

• Clinical Elements Identified:

  1. Medical History (phenotypes)
  2. Genetic Testing (FBN1 variants)
  3. Diagnosis

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📊 Sprint 2: Problem Analysis & Modelling

• Modelling Languages: UML (Class Diagram) & BPMN (Process Diagram)
• UML Class Diagram:
  • Entities: Patient, Provider, Lab, TestResultInterpretation, EHR
  • Key relationships and multiplicities (e.g. Provider 1..* ↔ Patient 1..*)
• BPMN Workflow:
  1. Patient schedules appointment
  2. Reception confirms/reschedules
  3. Clinician assesses & orders genetic test
  4. Lab performs test & returns results
  5. Clinician reviews results & delivers diagnosis
• Interoperability Layers:
  • Syntactic: Standard message formats & protocols
  • Semantic: Shared code systems (SNOMED CT, LOINC, ICD‑10)
  • Organizational & Process: Defined roles & handoffs

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📑 Project Sprint 3: CDA Implementation

• We authored a C‑CDA (Continuity of Care Document) instance containing all use‑case data (patient demographics, encounters, problems, procedures, results, consultation notes).
• Files:
  • cda/PS3‑FibrillinGenies_CCD.xml (full CDA template)
  • cda/Screenshot_of_CDA_Viewer.png (CDA Viewer screenshot)

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🔄 Project Sprint 4: XSLT‑Driven Interoperability

Goal: Transform the CDA into the payloads each system needs.

• System A: OpenMRS (EMR, accepts JSON)
• System B: OpenELIS (LIMS, accepts XML)

Sections & XSLTs

Section	Purpose	CDA → OpenMRS JSON	OpenMRS JSON → OpenELIS XML
Patient Details	Demographics & identifiers	xslt/PatientDetails.xsl	xslt/patdetailsSysB.xsl
Encounters	Visit date/time, type, location, providers	xslt/encounter.xsl	N/A
Problem List	Active findings (pectus excavatum, etc.)	xslt/ProblemList.xsl + xslt/problemlist.json	N/A
Procedures	Genetic test order (FBN1)	xslt/Procedure.xsl	xslt/ProceSysB.xsl
Results	Genetic test outcomes (positive/negative)	xslt/Results.xsl	xslt/ResultsSysB.xsl

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📂 Repo Structure

/. ├── docs/ │ └── HST‑PS4‑FibrillinGenies.docx ├── cda/ │ ├── PS3‑FibrillinGenies_CCD.xml │ └── Screenshot_of_CDA_Viewer.png ├── xslt/ │ ├── PatientDetails.xsl │ ├── patdetailsSysB.xsl │ ├── encounter.xsl │ ├── ProblemList.xsl │ ├── problemlist.json │ ├── Procedure.xsl │ ├── ProceSysB.xsl │ ├── Results.xsl │ └── ResultsSysB.xsl └── README.md

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⚙️ Getting Started

1. Clone this repo

   git clone https://github.com/Hemanth-072/Health-Care-Interoperability-projects.git
   

   cd Health-Care-Interoperability-projects

   Install an XSLT processor (e.g. Oxygen XML, Saxon).

   Run transformations:

    Patient → OpenMRS JSON
   

saxon -s:cda/PS3‑FibrillinGenies_CCD.xml
-xsl:xslt/PatientDetails.xsl
-o:out/patient.json

Patient JSON → OpenELIS XML

    saxon -it -xsl:xslt/patdetailsSysB.xsl \
          -val:input=out/patient.json \
          -o:out/patient_sysb.xml

    Repeat for encounter.xsl, ProblemList.xsl, Procedure.xsl, Results.xsl and their System B counterparts.

🔗 Cloning Our GitHub Repo

You can always get the latest source and files by cloning:

git clone https://github.com/Hemanth-072/Health-Care-Interoperability-projects.git

📚 References

OpenMRS Product Overview: https://openmrs.org/product/

OpenELIS Global LIMS: https://openelis-global.org/

HL7 C‑CDA R2 Implementation Guide

Visual Paradigm UML & BPMN tutorials