Rapid geneset preservation analysis between two experimental conditions (eg. disease cases vs. healthy controls).
Written by: Michael S. Breen, PhD
Contact: michael.breen@mssm.edu
File descriptions:
RapidPreservation.R = Rscript that will execute the preservation analysis. This script has several dependencies: 1) R libraries WGCNA, GeneOverlap and clusterRepro 2) two user defined matrices (e.g. case matrix and control matrix), which as a rule of thumb should contain greater than 15 samples per matrix, and 3) a curated .gmt file of pathways to test for preservation.
Pathways4Preservation.gmt = .gmt file of pathways to be tested