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This directory contains code that enables geneset preservation analyses between two experimental conditions (e.g. cases vs. healthy controls).

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BreenMS/Geneset-preservation-analysis

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Rapid geneset preservation analysis between two experimental conditions (eg. disease cases vs. healthy controls).

Written by: Michael S. Breen, PhD
Contact: michael.breen@mssm.edu

File descriptions:
RapidPreservation.R = Rscript that will execute the preservation analysis. This script has several dependencies: 1) R libraries WGCNA, GeneOverlap and clusterRepro 2) two user defined matrices (e.g. case matrix and control matrix), which as a rule of thumb should contain greater than 15 samples per matrix, and 3) a curated .gmt file of pathways to test for preservation.
Pathways4Preservation.gmt = .gmt file of pathways to be tested

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This directory contains code that enables geneset preservation analyses between two experimental conditions (e.g. cases vs. healthy controls).

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