MyDisease MCP Server

A Model Context Protocol (MCP) server that provides access to the MyDisease.info API.

Features

Core Capabilities

• Disease Search: Search by name, ID, symptom, or any text field
• Gene Associations: Find diseases associated with specific genes
• Variant Analysis: Get disease associations for genetic variants
• Phenotype Mapping: Search diseases by HPO terms and clinical features
• Clinical Data: Access ClinVar annotations and clinical significance
• Disease Ontology: Navigate disease classifications and relationships
• GWAS Data: Explore genome-wide association studies
• Pathway Analysis: Find diseases affecting specific biological pathways
• Drug Information: Get treatment options and drug-disease relationships
• Epidemiology: Access prevalence, incidence, and demographic data
• Batch Processing: Query up to 1000 diseases in a single request
• Data Export: Export results in TSV, CSV, JSON, or Markdown formats

Data Sources

• OMIM: Online Mendelian Inheritance in Man
• Orphanet: Rare disease database
• DisGeNET: Gene-disease associations
• ClinVar: Clinical variant interpretations
• HPO: Human Phenotype Ontology
• GWAS Catalog: NHGRI-EBI GWAS studies
• CTD: Comparative Toxicogenomics Database
• KEGG: Disease pathways
• UniProt: Protein-disease associations

Prerequisites

• Python 3.12+ with pip

Quick Start

1. Install UV

UV is a fast Python package and project manager.

pip install uv

2. Install MCPM (MCP Manager)

MCPM is a package manager for MCP servers that simplifies installation and configuration.

pip install mcpm

3. Setup the MCP Server

cd mydisease-mcp
uv sync

4. Add the Server to Claude Desktop

# Make sure you're in the project directory
cd mydisease-mcp

# Set Claude as the target client
mcpm target set @claude-desktop

# Add the MyDisease MCP server
mcpm import stdio mydisease \
  --command "$(uv run which python)" \
  --args "-m mydisease_mcp.server"

Then restart Claude Desktop.

Usage

Running the Server

uv run python -m mydisease_mcp.server

Development

# Run tests
uv run pytest tests/ -v