What is considered a large store that results in poor performance?

[ruanspies]

Is there a rule of thumb to give an indication that size of the store may result in performance issues?

I understand that one can test this out and run some benchmarking/profiling tests for a specific application but was wondering if there is a general way to anticipate that something may be too large?

[posva]

First rule of optimization: don't anticipate it!
Profile it and then optimize it