<!-- For general questions please use the Discussions section of the project: https://github.com/bihealth/varfish-server/discussions For bug reports and feature requests please open a ticket using the templates! --> **Is your feature request related to a problem? Please describe.** Regional constraint scores are essential for variant interpretation. We have none. **Describe the solution you'd like** Add support for [Metadome](https://stuart.radboudumc.nl/metadome/method) data. **Describe alternatives you've considered** N/A **Additional context** - [UCSC Regional Constraint Scores](https://genome.ucsc.edu/cgi-bin/hgTrackUi?hgsid=1512549847_v4X2WPQm6FNpXJFlabYACycpqXOA&db=hg38&c=chr14&g=constraintSuper)