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sofianatale/README.md

Hi there, I’m Sofia

👩🏻‍💻 MSc Student in Bioinformatics at University of Bologna
🎓 BSc in Biological Sciences at University of Ferrara

💡 About Me

I focus on developing computational approaches for biological data analysis, combining algorithmic methods with molecular insight.
Currently exploring how machine learning and genomic technologies can be integrated into reproducible pipelines for data-driven research.

🧬 Interests

  • Machine Learning & Predictive Modeling in Biology
  • Genomics and Epigenomics
  • Biomedical Data Pipelines and Workflow Automation
  • In Silico Biology and Systems Thinking
  • Molecular Network Analysis
  • Data-Driven Discovery and Model Interpretation

💻 Technical Skills

  • Programming & Tools: Python, R, Bash/Linux, Git/GitHub, Conda
  • Libraries: NumPy, Pandas, Matplotlib, scikit-learn, Biopython
  • Bioinformatics: HMMER, BLAST+, CD-HIT, InterProScan
  • Epigenomics: minfi, methylKit
  • Machine Learning: SVM, Random Forest, Logistic Regression, PCA, MCC, ROC/AUC
  • Systems Biology: Cytoscape, STRING, KEGG, Reactome
  • HPC & Pipelines: Workflow automation, parallel computing, job scheduling
  • Wet Lab: Molecular biology foundation; experience with Western blot, immunofluorescence, microscopy

📂 Projects

Design of a structure-guided Hidden Markov Model for the Kunitz-type protease inhibitor domain, integrating PDBeFold alignments, redundancy reduction (CD-HIT), and binary cross-validation with HMMER.

A comprehensive multi-omics study on the Alpine marmot (Marmota marmota), integrating genomic, transcriptomic, and epigenomic layers to explore environmental adaptation mechanisms.

A methylation-analysis pipeline in R for Illumina 450K data: preprocessing, QC, normalization, PCA, and DMP detection between control and disease.

🌐 Connect with Me

GitHub LinkedIn Email

Popular repositories Loading

  1. LAB1_project LAB1_project Public

    Development of a structure-driven HMM for the Kunitz domain (PF00014), combining curated 3D alignments and robust statistical evaluation. Project created during the MSc in Bioinformatics at the Uni…

    Jupyter Notebook

  2. DNARNA_Group4 DNARNA_Group4 Public

    Forked from Martinaa1408/DNARNA_Group4

    This repository contains the final project of Group 4 for the DNA/RNA Dynamics course (MSc Bioinformatics, University of Bologna). It provides a full Illumina 450K methylation analysis pipeline in …

    HTML

  3. Applied_Genomics Applied_Genomics Public

    This repository collects my project for the Applied Genomics course. It includes the presentation on the chromosome-scale reference genome of the Alpine marmot, integrating multi-omics to study hib…

  4. sofianatale sofianatale Public