diff --git a/.github/workflows/integration-tests.yml b/.github/workflows/integration-tests.yml
index 89095817..64c8aafa 100644
--- a/.github/workflows/integration-tests.yml
+++ b/.github/workflows/integration-tests.yml
@@ -16,32 +16,22 @@ jobs:
         python-version: ["3.8", "3.11", "3.12"]
 
     steps:
-    - uses: actions/checkout@v3
-    - name: Set up Python ${{ matrix.python-version }}
-      uses: actions/setup-python@v5
+    - uses: actions/checkout@v4
+    - name: Install uv
+      uses: astral-sh/setup-uv@v5
       with:
+        enable-cache: true
         python-version: ${{ matrix.python-version }}
 
-    - name: Cache pip
-      uses: actions/cache@v4
-      with:
-        path: ~/.cache/pip
-        key: ${{ runner.os }}-pip-${{ hashFiles('**/requirements-test.txt') }}
-        restore-keys: |
-          ${{ runner.os }}-pip-
-
     - name: Setup java
       uses: actions/setup-java@v4
       with:
         distribution: 'temurin'
-        java-version: '11'
+        java-version: '8'
 
     - name: Install dependencies
-      run: |       
-        pip install -U pip setuptools
-        pip install .
-
-        if [ -f requirements-test.txt ]; then pip install -r requirements-test.txt; fi
+      run: |
+        uv sync
 
     - name: Cache binary versions
       id: cache-versions
@@ -59,6 +49,7 @@ jobs:
     - name: Download versions
       if: steps.cache-versions.outputs.cache-hit != 'true'
       run: |
+        source ${{ env.VIRTUAL_ENV }}/bin/activate
         normalized=$(echo ${{ inputs.reloc_version }} | tr ':' '_')
         if [ ! -f ~/.ccm/scylla-repository/unstable/master/$normalized ]; then
           ./ccm create temp -n 1 --scylla --version unstable/master:${{ inputs.reloc_version }}
@@ -69,7 +60,7 @@ jobs:
 
     - name: Test with pytest
       run: |
-        python -m pytest ./tests -x
+        uv run python -m pytest ./tests -x
 
     - name: Copy logs/results
       if: contains(github.event.pull_request.labels.*.name, 'PR-upload-log')
diff --git a/.gitignore b/.gitignore
index c29d413e..93ca2562 100644
--- a/.gitignore
+++ b/.gitignore
@@ -14,4 +14,6 @@ tests/test_results
 .vscode/
 
 .envrc
-ccmlib/tests/
\ No newline at end of file
+ccmlib/tests/
+
+uv.lock
\ No newline at end of file
diff --git a/.python-version b/.python-version
new file mode 100644
index 00000000..e4fba218
--- /dev/null
+++ b/.python-version
@@ -0,0 +1 @@
+3.12
diff --git a/README.md b/README.md
index 9aad3eee..dc259fa9 100644
--- a/README.md
+++ b/README.md
@@ -56,7 +56,7 @@ Requirements
 ------------
 
 - A working python installation (tested to work with python 3.12).
-- `pip install -e .` to install the required dependencies.
+- [UV](https://docs.astral.sh/uv)
 - Java if cassandra is used or older scylla < 6.0 (which version depends on the version 
   of Cassandra you plan to use. If unsure, use Java 8 as it is known to 
   work with current versions of Cassandra).
@@ -80,9 +80,11 @@ Known issues
 Installation
 ------------
 
-ccm uses python setuptools (with distutils fallback) so from the source directory run:
+ccm uses UV with setuptools as a build system (with distutils fallback) so from the source directory run:
 
-    sudo ./setup.py install
+    uv python install
+    uv venv .venv-ccm
+    uv sync
 
 ccm is available on the [Python Package Index][pip]:
 
diff --git a/ccm b/ccm
index 076baa2a..6adac75f 100755
--- a/ccm
+++ b/ccm
@@ -40,35 +40,39 @@ def print_global_usage():
     exit(1)
 
 
-common.check_win_requirements()
+def main():
+    common.check_win_requirements()
 
-if len(sys.argv) <= 1:
-    print("Missing arguments")
-    print_global_usage()
-
-arg1 = sys.argv[1].lower()
-
-if arg1 in cluster_cmds.cluster_cmds():
-    kind = 'cluster'
-    cmd = arg1
-    cmd_args = sys.argv[2:]
-else:
-    if len(sys.argv) <= 2:
+    if len(sys.argv) <= 1:
         print("Missing arguments")
         print_global_usage()
-    kind = 'node'
-    node = arg1
-    cmd = sys.argv[2]
-    cmd_args = [node] + sys.argv[3:]
-
-cmd = get_command(kind, cmd)
-if not cmd:
-    print("Unknown node or command: {0}".format(arg1))
-    exit(1)
 
-parser = cmd.get_parser()
+    arg1 = sys.argv[1].lower()
+
+    if arg1 in cluster_cmds.cluster_cmds():
+        kind = 'cluster'
+        cmd = arg1
+        cmd_args = sys.argv[2:]
+    else:
+        if len(sys.argv) <= 2:
+            print("Missing arguments")
+            print_global_usage()
+        kind = 'node'
+        node = arg1
+        cmd = sys.argv[2]
+        cmd_args = [node] + sys.argv[3:]
+
+    cmd = get_command(kind, cmd)
+    if not cmd:
+        print("Unknown node or command: {0}".format(arg1))
+        exit(1)
+
+    parser = cmd.get_parser()
+
+    (options, args) = parser.parse_args(cmd_args)
+    cmd.validate(parser, options, args)
 
-(options, args) = parser.parse_args(cmd_args)
-cmd.validate(parser, options, args)
+    cmd.run()
 
-cmd.run()
+if __name__ == '__main__':
+    main()
\ No newline at end of file
diff --git a/pyproject.toml b/pyproject.toml
new file mode 100644
index 00000000..7be89c4a
--- /dev/null
+++ b/pyproject.toml
@@ -0,0 +1,60 @@
+[project]
+name = "ccm"
+version = "0.1.0"
+license = { file = "license.txt"}
+description = "Cassandra Cluster Manager"
+authors = [
+    {name = "Sylvain Lebresne", email = "sylvain@datastax.com"}
+]
+maintainers = [
+ {name="ScyllaDB Contributors"}
+]
+readme = "README.md"
+requires-python = ">=3.8"
+dependencies = [
+    "ruamel-yaml",
+    "psutil",
+    "requests",
+    "packaging",
+    "boto3",
+    "tqdm",
+    "urllib3 < 2",
+]
+[project.urls]
+Repository = "https://github.com/scylladb/scylla-ccm"
+Issues = "https://github.com/scylladb/scylla-ccm/issues"
+
+[project.scripts]
+ccm = "ccm:main"
+
+[dependency-groups]
+dev = [
+  "pytest",
+  "awscli"
+]
+[tool.setuptools]
+packages = ["ccmlib", "ccmlib.cmds", "ccmlib.utils"]
+
+[tool.pytest.ini_options]
+python_classes = ["*Test", "Test*"]
+python_files = ["test_*", "*_test"]
+python_functions = ["test_*", "*_test"]
+testpaths = "tests"
+norecursedirs = [".*", "ssl", "*.egg-info", "ccmlib", "docs"]
+log_cli = true
+log_cli_level = "ERROR"
+log_level = "DEBUG"
+log_format = "%(asctime)s %(levelname)-8s %(message)s"
+log_date_format = "%Y-%m-%d %H:%M:%S"
+log_file = "tests/test_results/ccm.log"
+markers = [
+  "docker: Run tests with docker image",
+  "reloc: Run tests with relocatable packages",
+  "cassandra: Run tests with cassandra binaries",
+  "repo_tests: Run test for testing get versions"
+]
+filterwarnings = ["error", "ignore::ResourceWarning"]
+
+[build-system]
+requires = ["setuptools >= 61.0"]
+build-backend = "setuptools.build_meta"
diff --git a/pytest.ini b/pytest.ini
deleted file mode 100644
index 43b43827..00000000
--- a/pytest.ini
+++ /dev/null
@@ -1,21 +0,0 @@
-[pytest]
-python_classes = *Test Test*
-python_files = test_* *_test
-python_functions = test_* *_test
-testpaths = tests
-norecursedirs = .* ssl *.egg-info ccmlib docs
-log_cli=true
-log_cli_level = ERROR
-log_level = DEBUG
-log_format = %(asctime)s %(levelname)-8s %(message)s
-log_date_format = %Y-%m-%d %H:%M:%S
-log_file= tests/test_results/ccm.log
-markers = 
-  docker: Run tests with docker image
-  reloc: Run tests with relocatable packages
-  cassandra: Run tests with cassandra binaries
-  repo_tests: Run test for testing get versions
-
-filterwarnings =
-    error
-    ignore::ResourceWarning
diff --git a/requirements-test.txt b/requirements-test.txt
deleted file mode 100644
index 1b3d9bbe..00000000
--- a/requirements-test.txt
+++ /dev/null
@@ -1,2 +0,0 @@
-pytest
-awscli
\ No newline at end of file
diff --git a/setup.py b/setup.py
deleted file mode 100755
index 94372e82..00000000
--- a/setup.py
+++ /dev/null
@@ -1,39 +0,0 @@
-#!/usr/bin/env python
-
-from os.path import abspath, join, dirname
-from platform import system
-from shutil import copyfile
-
-try:
-    from setuptools import setup
-except ImportError:
-    from distutils.core import setup
-
-ccmscript = 'ccm'
-if system() == "Windows":
-    copyfile('ccm', 'ccm.py')
-    ccmscript = 'ccm.py'
-
-setup(
-    name='ccm',
-    version='2.0.5',
-    description='Cassandra Cluster Manager',
-    long_description=open(abspath(join(dirname(__file__), 'README.md'))).read(),
-    author='Sylvain Lebresne',
-    author_email='sylvain@datastax.com',
-    url='https://github.com/pcmanus/ccm',
-    packages=['ccmlib', 'ccmlib.cmds', 'ccmlib.utils'],
-    scripts=[ccmscript],
-    install_requires=['ruamel.yaml', 'psutil', 'requests', 'packaging', 'boto3', 'tqdm', 'urllib3<2'],
-    tests_require=['pytest'],
-    classifiers=[
-        "License :: OSI Approved :: Apache Software License",
-        "Programming Language :: Python",
-        'Programming Language :: Python :: 3',
-        'Programming Language :: Python :: 3.8',
-        'Programming Language :: Python :: 3.9'
-        'Programming Language :: Python :: 3.11'
-        'Programming Language :: Python :: 3.12'
-    ],
-    include_package_data=True,
-)