diff --git a/.gitignore b/.gitignore
index e53642de..d46ced73 100644
--- a/.gitignore
+++ b/.gitignore
@@ -1,3 +1,2 @@
 cmd/bin
-images/.qemu-user-static.created
 images/calico-go-build/bin
diff --git a/.semaphore/promotions/qemu-user-static.yml b/.semaphore/promotions/qemu-user-static.yml
deleted file mode 100644
index 8f70ac83..00000000
--- a/.semaphore/promotions/qemu-user-static.yml
+++ /dev/null
@@ -1,34 +0,0 @@
-version: v1.0
-name: Publish calico/qemu-user-static image
-agent:
-  machine:
-    type: f1-standard-2
-    os_image: ubuntu2204
-
-execution_time_limit:
-  minutes: 30
-
-global_job_config:
-  env_vars:
-    - name: DEV_REGISTRIES
-      value: calico
-  secrets:
-    - name: docker
-  prologue:
-    commands:
-      - echo $DOCKER_TOKEN | docker login --username "$DOCKER_USER" --password-stdin
-      - checkout
-
-blocks:
-  - name: Publish calico/qemu-user-static amd64 image
-    dependencies: []
-    run:
-      when: "branch = 'master' OR tag =~ '^1\\.\\d+\\.\\d-llvm\\d+\\.\\d\\.\\d-k8s1\\.\\d+\\.\\d'"
-    task:
-      env_vars:
-        - name: BRANCH_NAME
-          value: latest
-      jobs:
-        - name: Linux amd64
-          commands:
-            - if [ -z "${SEMAPHORE_GIT_PR_NUMBER}" ]; then make -C images qemu-user-static-cd CONFIRM=true; fi
diff --git a/.semaphore/semaphore.yml b/.semaphore/semaphore.yml
index fe9ee9dd..ebfad530 100644
--- a/.semaphore/semaphore.yml
+++ b/.semaphore/semaphore.yml
@@ -40,10 +40,6 @@ promotions:
     pipeline_file: promotions/calico-go-build.yml
     auto_promote:
       when: "branch = 'master' OR tag =~ '^1\\.\\d+\\.\\d-llvm\\d+\\.\\d\\.\\d-k8s1\\.\\d+\\.\\d'"
-  - name: Publish calico/qemu-user-static image
-    pipeline_file: promotions/qemu-user-static.yml
-    auto_promote:
-      when: "branch = 'master' OR tag =~ '^1\\.\\d+\\.\\d-llvm\\d+\\.\\d\\.\\d-k8s1\\.\\d+\\.\\d'"
 
 blocks:
   - name: calico/go-build image
diff --git a/Makefile.common b/Makefile.common
index c0138586..b83be6f4 100644
--- a/Makefile.common
+++ b/Makefile.common
@@ -75,7 +75,7 @@ endif
 # This is only needed when running non-native binaries.
 register:
 ifneq ($(BUILDARCH),$(ARCH))
-	docker run --rm --privileged multiarch/qemu-user-static:register || true
+	docker run --privileged --rm tonistiigi/binfmt --install all || true
 endif
 
 # If this is a release, also tag and push additional images.
diff --git a/README.md b/README.md
index 319185fc..f3666292 100644
--- a/README.md
+++ b/README.md
@@ -51,7 +51,7 @@ For example, if you registered the `s390x` emulator at `/usr/bin/qemu-s390x-stat
 To register emulators, we run:
 
 ```bash
-docker run -it --rm --privileged multiarch/qemu-user-static:register
+docker run --privileged --rm tonistiigi/binfmt --install all
 ```
 
 or simply
@@ -69,7 +69,7 @@ To _run_ a binary from a different architecture, you need to use `binfmt` and `q
 Register `qemu-*-static` for all supported processors except the current one using the following command:
 
 ```bash
-docker run --rm --privileged multiarch/qemu-user-static:register
+docker run --privileged --rm tonistiigi/binfmt --install all
 ```
 
 If a cross built binary is executed in the go-build container qemu-static will automatically be used.
diff --git a/cmd/Makefile b/cmd/Makefile
index 628f1a99..797503cb 100644
--- a/cmd/Makefile
+++ b/cmd/Makefile
@@ -6,7 +6,8 @@ build: semvalidator-build-$(ARCH)
 
 .PHONY: semvalidator-build-$(ARCH)
 semvalidator-build-$(ARCH): semvalidator/main.go
-	CGO_ENABLED=0 go build -o bin/semvalidator-$(ARCH) -v -buildvcs=false -ldflags "-s -w" semvalidator/main.go
+	CGO_ENABLED=0 GOOS=linux GOARCH=$(ARCH) \
+		go build -o bin/semvalidator-$(ARCH) -v -buildvcs=false -ldflags "-s -w" semvalidator/main.go
 
 .PHONY: clean
 clean:
diff --git a/images/Makefile b/images/Makefile
index fcdf1c92..7ddac966 100644
--- a/images/Makefile
+++ b/images/Makefile
@@ -6,28 +6,11 @@ VERSION_TAG ?= latest
 CALICO_BASE ?= base
 CALICO_GO_BUILD ?= go-build
 
-QEMU_USER_STATIC ?= $(DEV_REGISTRIES)/qemu-user-static
-QEMU_USER_STATIC_IMAGE_CREATED = .qemu-user-static.created
-
 .PHONY: image
-image: qemu-user-static-image calico-base-image calico-go-build-image
+image: calico-base-image calico-go-build-image
 
 .PHONY: image-all
-image-all: qemu-user-static-image calico-base-image-all calico-go-build-image-all
-
-# Holder image for all qemu-*-static binaries Calico supports.
-# It only builds for linux/amd64 platform.
-.PHONY: qemu-user-static-image
-qemu-user-static-image: $(QEMU_USER_STATIC_IMAGE_CREATED)
-$(QEMU_USER_STATIC_IMAGE_CREATED):
-	docker buildx build $(DOCKER_PROGRESS) --load --platform=linux/amd64 --pull \
-		-t $(QEMU_USER_STATIC):latest \
-		-f qemu-user-static/Dockerfile qemu-user-static/
-	touch $@
-
-.PHONY: qemu-user-static-cd
-qemu-user-static-cd: qemu-user-static-image
-	docker push $(QEMU_USER_STATIC):latest
+image-all: calico-base-image-all calico-go-build-image-all
 
 # Base image for all calico components.
 
@@ -44,7 +27,7 @@ else ifeq ($(ARCH),s390)
 endif
 
 .PHONY: calico-base-image
-calico-base-image: register qemu-user-static-image
+calico-base-image: register
 	$(DOCKER_BUILD) --build-arg LDSONAME=$(LDSONAME) -t $(CALICO_BASE):latest-$(ARCH) -f calico-base/Dockerfile calico-base/
 	$(MAKE) BUILD_IMAGES=$(CALICO_BASE) retag-build-images-with-registries VALIDARCHES=$(ARCH) IMAGETAG=latest
 
@@ -65,7 +48,7 @@ build:
 	cp ../cmd/bin/semvalidator-$(ARCH) calico-go-build/bin/semvalidator-$(ARCH)
 
 .PHONY: calico-go-build-image
-calico-go-build-image: register qemu-user-static-image build
+calico-go-build-image: register build
 	$(DOCKER_BUILD) -t $(CALICO_GO_BUILD):latest-$(ARCH) -f calico-go-build/Dockerfile calico-go-build/
 	$(MAKE) BUILD_IMAGES=$(CALICO_GO_BUILD) retag-build-images-with-registries VALIDARCHES=$(ARCH) IMAGETAG=$(VERSION_TAG)
 
@@ -80,11 +63,9 @@ calico-go-build-cd: calico-go-build-image-all
 
 .PHONY: clean
 clean:
-	rm -f $(QEMU_USER_STATIC_IMAGE_CREATED)
 	rm -fr calico-go-build/bin
 	-docker image rm -f $$(docker images $(CALICO_BASE) -a -q)
 	-docker image rm -f $$(docker images $(CALICO_GO_BUILD) -a -q)
-	-docker image rm -f $$(docker images $(QEMU_USER_STATIC) -a -q)
 
 .PHONY: cd-common
 cd-common: var-require-one-of-CONFIRM-DRYRUN var-require-all-BRANCH_NAME
diff --git a/images/calico-base/Dockerfile b/images/calico-base/Dockerfile
index 7531a2b6..4d87bb48 100644
--- a/images/calico-base/Dockerfile
+++ b/images/calico-base/Dockerfile
@@ -1,10 +1,7 @@
-FROM --platform=linux/amd64 calico/qemu-user-static:latest AS qemu
-
 FROM registry.access.redhat.com/ubi8/ubi-minimal:latest AS ubi
 
 ARG LDSONAME
-
-COPY --from=qemu /usr/bin/qemu-*-static /usr/bin/
+ARG TARGETARCH
 
 RUN microdnf upgrade -y
 
@@ -13,12 +10,16 @@ RUN microdnf upgrade -y
 RUN mkdir -p /rootfs/lib64 /rootfs/etc
 
 # Copy dynamic loader and symbolic links.
-# Note: The dynamic loader name and links might be different in a future release.
+# For s390x architecture, modify the /lib/${LDSONAME} symlink to ../lib64/${LDSONAME}
+# instead of /usr/lib64 as the /usr/lib64 directory is not included in our base.
 RUN cp /lib64/ld-2.28.so /rootfs/lib64/ld-2.28.so
 RUN set -eux; \
     cp -a /lib64/${LDSONAME} /rootfs/lib64/${LDSONAME}; \
     if [ -f /lib/${LDSONAME} ]; then \
         mkdir -p /rootfs/lib && cp -a /lib/${LDSONAME} /rootfs/lib/${LDSONAME}; \
+        if [ "${TARGETARCH}" = "s390x" ]; then \
+            ln -sf ../lib64/${LDSONAME} /rootfs/lib/${LDSONAME}; \
+        fi \
     fi
 
 # Required external C dependencies for CGO builds.
@@ -42,6 +43,10 @@ FROM scratch AS source
 
 COPY --from=ubi /rootfs /
 
+# Verify if glibc can be properly loaded.
+# This check ensures that the dynamic loader and symbolic links are copied correctly.
+RUN ["/lib64/libc.so.6"]
+
 # tmp.tar has a /tmp with the correct permissions 01777.
 ADD tmp.tar /
 
diff --git a/images/calico-go-build/Dockerfile b/images/calico-go-build/Dockerfile
index a3b5eab5..f196d10b 100644
--- a/images/calico-go-build/Dockerfile
+++ b/images/calico-go-build/Dockerfile
@@ -2,8 +2,6 @@ ARG TARGETARCH=${TARGETARCH}
 
 FROM calico/bpftool:v7.4.0 AS bpftool
 
-FROM --platform=amd64 calico/qemu-user-static:latest AS qemu
-
 FROM registry.access.redhat.com/ubi8/ubi:latest AS ubi
 
 ARG TARGETARCH
@@ -16,10 +14,6 @@ ARG YQ_VERSION=v4.45.1
 
 ENV PATH=/usr/local/go/bin:$PATH
 
-# Enable non-native runs on amd64 architecture hosts
-# Supported qemu-user-static arch files are copied in Makefile `download-qemu` target
-COPY --from=qemu /usr/bin/qemu-*-static /usr/bin
-
 # Install system dependencies
 RUN dnf upgrade -y && dnf install -y \
     autoconf \
diff --git a/images/qemu-user-static/Dockerfile b/images/qemu-user-static/Dockerfile
deleted file mode 100644
index 2f8dca26..00000000
--- a/images/qemu-user-static/Dockerfile
+++ /dev/null
@@ -1,14 +0,0 @@
-FROM fedora:latest AS qemu
-
-RUN dnf install -y qemu-user-static
-
-FROM scratch AS source
-
-COPY --from=qemu /usr/bin/qemu-aarch64-static /usr/bin/qemu-aarch64-static
-COPY --from=qemu /usr/bin/qemu-ppc64le-static /usr/bin/qemu-ppc64le-static
-COPY --from=qemu /usr/bin/qemu-s390x-static /usr/bin/qemu-s390x-static
-COPY --from=qemu /usr/bin/qemu-x86_64-static /usr/bin/qemu-x86_64-static
-
-FROM scratch
-
-COPY --from=source / /