diff --git a/CHANGELOG.md b/CHANGELOG.md
index ec04582110ad..09c685badc34 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -2,6 +2,8 @@
 
 ## Unreleased
 
+## Version 2.21.0 (2025-10-17)
+
 ## ⚠️ Breaking Changes
 
 - Hadoop JMX metrics have been renamed to align with semantic conventions.
diff --git a/docs/apidiffs/current_vs_latest/opentelemetry-instrumentation-annotations.txt b/docs/apidiffs/current_vs_latest/opentelemetry-instrumentation-annotations.txt
index 1c04a7765130..853dfdefa3f5 100644
--- a/docs/apidiffs/current_vs_latest/opentelemetry-instrumentation-annotations.txt
+++ b/docs/apidiffs/current_vs_latest/opentelemetry-instrumentation-annotations.txt
@@ -1,2 +1,2 @@
-Comparing source compatibility of opentelemetry-instrumentation-annotations-2.21.0-SNAPSHOT.jar against opentelemetry-instrumentation-annotations-2.20.1.jar
+Comparing source compatibility of opentelemetry-instrumentation-annotations-2.22.0-SNAPSHOT.jar against opentelemetry-instrumentation-annotations-2.20.1.jar
 No changes.
\ No newline at end of file
diff --git a/docs/apidiffs/current_vs_latest/opentelemetry-instrumentation-api.txt b/docs/apidiffs/current_vs_latest/opentelemetry-instrumentation-api.txt
index e83025516220..daf30c39fd6d 100644
--- a/docs/apidiffs/current_vs_latest/opentelemetry-instrumentation-api.txt
+++ b/docs/apidiffs/current_vs_latest/opentelemetry-instrumentation-api.txt
@@ -1,2 +1,2 @@
-Comparing source compatibility of opentelemetry-instrumentation-api-2.21.0-SNAPSHOT.jar against opentelemetry-instrumentation-api-2.20.1.jar
+Comparing source compatibility of opentelemetry-instrumentation-api-2.22.0-SNAPSHOT.jar against opentelemetry-instrumentation-api-2.20.1.jar
 No changes.
\ No newline at end of file
diff --git a/docs/apidiffs/current_vs_latest/opentelemetry-spring-boot-autoconfigure.txt b/docs/apidiffs/current_vs_latest/opentelemetry-spring-boot-autoconfigure.txt
index 3733a382e4dd..61214e54c823 100644
--- a/docs/apidiffs/current_vs_latest/opentelemetry-spring-boot-autoconfigure.txt
+++ b/docs/apidiffs/current_vs_latest/opentelemetry-spring-boot-autoconfigure.txt
@@ -1,2 +1,2 @@
-Comparing source compatibility of opentelemetry-spring-boot-autoconfigure-2.21.0-SNAPSHOT.jar against opentelemetry-spring-boot-autoconfigure-2.20.1.jar
+Comparing source compatibility of opentelemetry-spring-boot-autoconfigure-2.22.0-SNAPSHOT.jar against opentelemetry-spring-boot-autoconfigure-2.20.1.jar
 No changes.
\ No newline at end of file
diff --git a/docs/apidiffs/current_vs_latest/opentelemetry-spring-boot-starter.txt b/docs/apidiffs/current_vs_latest/opentelemetry-spring-boot-starter.txt
index ac64311a4178..1c22458fc07e 100644
--- a/docs/apidiffs/current_vs_latest/opentelemetry-spring-boot-starter.txt
+++ b/docs/apidiffs/current_vs_latest/opentelemetry-spring-boot-starter.txt
@@ -1,2 +1,2 @@
-Comparing source compatibility of opentelemetry-spring-boot-starter-2.21.0-SNAPSHOT.jar against opentelemetry-spring-boot-starter-2.20.1.jar
+Comparing source compatibility of opentelemetry-spring-boot-starter-2.22.0-SNAPSHOT.jar against opentelemetry-spring-boot-starter-2.20.1.jar
 No changes.
\ No newline at end of file
diff --git a/examples/distro/build.gradle b/examples/distro/build.gradle
index 975ac5ab0f16..cb8bc013ee69 100644
--- a/examples/distro/build.gradle
+++ b/examples/distro/build.gradle
@@ -14,7 +14,7 @@ buildscript {
   dependencies {
     classpath "com.diffplug.spotless:spotless-plugin-gradle:8.0.0"
     classpath "com.gradleup.shadow:shadow-gradle-plugin:9.2.2"
-    classpath "io.opentelemetry.instrumentation:gradle-plugins:2.21.0-alpha-SNAPSHOT"
+    classpath "io.opentelemetry.instrumentation:gradle-plugins:2.22.0-alpha-SNAPSHOT"
   }
 }
 
@@ -30,8 +30,8 @@ subprojects {
       opentelemetrySdk           : "1.55.0",
 
       // these lines are managed by .github/scripts/update-version.sh
-      opentelemetryJavaagent     : "2.21.0-SNAPSHOT",
-      opentelemetryJavaagentAlpha: "2.21.0-alpha-SNAPSHOT",
+      opentelemetryJavaagent     : "2.22.0-SNAPSHOT",
+      opentelemetryJavaagentAlpha: "2.22.0-alpha-SNAPSHOT",
 
       autoservice                : "1.1.1"
     ]
diff --git a/examples/extension/build.gradle b/examples/extension/build.gradle
index cdb1bdbce20a..f13f7cb9f248 100644
--- a/examples/extension/build.gradle
+++ b/examples/extension/build.gradle
@@ -13,8 +13,8 @@ plugins {
   id "com.gradleup.shadow" version "9.2.2"
   id "com.diffplug.spotless" version "8.0.0"
 
-  id "io.opentelemetry.instrumentation.muzzle-generation" version "2.21.0-alpha-SNAPSHOT"
-  id "io.opentelemetry.instrumentation.muzzle-check" version "2.21.0-alpha-SNAPSHOT"
+  id "io.opentelemetry.instrumentation.muzzle-generation" version "2.22.0-alpha-SNAPSHOT"
+  id "io.opentelemetry.instrumentation.muzzle-check" version "2.22.0-alpha-SNAPSHOT"
 }
 
 group 'io.opentelemetry.example'
@@ -26,8 +26,8 @@ ext {
     opentelemetrySdk           : "1.55.0",
 
     // these lines are managed by .github/scripts/update-version.sh
-    opentelemetryJavaagent     : "2.21.0-SNAPSHOT",
-    opentelemetryJavaagentAlpha: "2.21.0-alpha-SNAPSHOT"
+    opentelemetryJavaagent     : "2.22.0-SNAPSHOT",
+    opentelemetryJavaagentAlpha: "2.22.0-alpha-SNAPSHOT"
   ]
 
   deps = [
diff --git a/version.gradle.kts b/version.gradle.kts
index 0698ee034579..97b7c2a75c69 100644
--- a/version.gradle.kts
+++ b/version.gradle.kts
@@ -1,5 +1,5 @@
-val stableVersion = "2.21.0-SNAPSHOT"
-val alphaVersion = "2.21.0-alpha-SNAPSHOT"
+val stableVersion = "2.22.0-SNAPSHOT"
+val alphaVersion = "2.22.0-alpha-SNAPSHOT"
 
 allprojects {
   if (findProperty("otel.stable") != "true") {