diff --git a/modules/nextflow/src/main/groovy/nextflow/Session.groovy b/modules/nextflow/src/main/groovy/nextflow/Session.groovy
index d45f26c528..2a640d0e23 100644
--- a/modules/nextflow/src/main/groovy/nextflow/Session.groovy
+++ b/modules/nextflow/src/main/groovy/nextflow/Session.groovy
@@ -16,6 +16,8 @@
 
 package nextflow
 
+import nextflow.util.CacheHelper
+
 import java.nio.file.Files
 import java.nio.file.Path
 import java.nio.file.Paths
@@ -128,6 +130,11 @@ class Session implements ISession {
      */
     boolean resumeMode
 
+    /**
+     * whenever it has been launched with globalCache
+     */
+    boolean globalCache
+
     /**
      * The folder where workflow outputs are stored
      */
@@ -358,6 +365,10 @@ class Session implements ISession {
             resumeMode = true
             uniqueId = UUID.fromString(config.resume as String)
         }
+        else if ( config.globalcache ){
+            globalCache = true
+            uniqueId = UUID.nameUUIDFromBytes(CacheHelper.hasher(FileHelper.asPath(config.globalcache as String).normalize().toString()).hash().asBytes())
+        }
         else {
            uniqueId = systemEnv.get('NXF_UUID') ? UUID.fromString(systemEnv.get('NXF_UUID')) : UUID.randomUUID()
         }
diff --git a/modules/nextflow/src/main/groovy/nextflow/cli/CmdRun.groovy b/modules/nextflow/src/main/groovy/nextflow/cli/CmdRun.groovy
index d096e678e6..ce29864fff 100644
--- a/modules/nextflow/src/main/groovy/nextflow/cli/CmdRun.groovy
+++ b/modules/nextflow/src/main/groovy/nextflow/cli/CmdRun.groovy
@@ -121,6 +121,9 @@ class CmdRun extends CmdBase implements HubOptions {
     @Parameter(names=['-with-cloudcache'], description = 'Enable the use of object storage bucket as storage for cache meta-data')
     String cloudCachePath
 
+    @Parameter(names=['-with-globalcache'], description = 'Enable the use of a global cache meta-data')
+    String globalCachePath
+
     /**
      * Defines the parameters to be passed to the pipeline script
      */
@@ -316,7 +319,12 @@ class CmdRun extends CmdBase implements HubOptions {
 
         if( offline && latest )
             throw new AbortOperationException("Command line options `-latest` and `-offline` cannot be specified at the same time")
-
+        if( globalCachePath && workDir )
+            throw new AbortOperationException("Command line options `-with-globalcache` and `-workdir` cannot be specified at the same time. Global cache already set the 'workDir")
+        if( globalCachePath && cloudCachePath )
+            throw new AbortOperationException("Command line options `-with-globalcache` and `-with-cloudcache` cannot be specified at the same time. Global cache already set the 'cloudcache'")
+        if( globalCachePath && resume )
+            throw new AbortOperationException("Command line options `-with-globalCache` and `-resume` cannot be specified at the same time. '-resume' is implicitly activated in global cache runs")
         checkRunName()
 
         printBanner()
diff --git a/modules/nextflow/src/main/groovy/nextflow/config/ConfigBuilder.groovy b/modules/nextflow/src/main/groovy/nextflow/config/ConfigBuilder.groovy
index 0341f73523..23485c564e 100644
--- a/modules/nextflow/src/main/groovy/nextflow/config/ConfigBuilder.groovy
+++ b/modules/nextflow/src/main/groovy/nextflow/config/ConfigBuilder.groovy
@@ -531,6 +531,12 @@ class ConfigBuilder {
     @PackageScope
     void configRunOptions(ConfigObject config, Map env, CmdRun cmdRun) {
 
+        if( cmdRun.globalCachePath ) {
+            log.warn("Enabling global cache. This will overwrite 'cloudcache' and 'workDir' parameters.")
+            config.globalcache = cmdRun.globalCachePath
+            cmdRun.workDir = "${cmdRun.globalCachePath}/work"
+            cmdRun.cloudCachePath = "${cmdRun.globalCachePath}/.nf-global-cache"
+        }
         // -- set config options
         if( cmdRun.cacheable != null )
             config.cacheable = cmdRun.cacheable
diff --git a/modules/nextflow/src/main/groovy/nextflow/processor/TaskProcessor.groovy b/modules/nextflow/src/main/groovy/nextflow/processor/TaskProcessor.groovy
index c4860deaeb..7fec7879f2 100644
--- a/modules/nextflow/src/main/groovy/nextflow/processor/TaskProcessor.groovy
+++ b/modules/nextflow/src/main/groovy/nextflow/processor/TaskProcessor.groovy
@@ -2418,7 +2418,7 @@ class TaskProcessor {
     }
 
     @PackageScope boolean isResumable() {
-        isCacheable() && session.resumeMode
+        isCacheable() && (session.resumeMode || session.globalCache)
     }
 
     /**