diff --git a/src/mcp/server/lowlevel/server.py b/src/mcp/server/lowlevel/server.py
index 562de31b7..db17ebe46 100644
--- a/src/mcp/server/lowlevel/server.py
+++ b/src/mcp/server/lowlevel/server.py
@@ -67,6 +67,7 @@ async def main():
 
 from __future__ import annotations as _annotations
 
+import asyncio
 import contextvars
 import json
 import logging
@@ -647,6 +648,12 @@ async def _handle_request(
                 response = await handler(req)
             except McpError as err:
                 response = err.error
+            except asyncio.CancelledError:
+                logger.info(
+                    "Request %s cancelled - duplicate response suppressed",
+                    message.request_id,
+                )
+                return
             except Exception as err:
                 if raise_exceptions:
                     raise err
diff --git a/tests/server/test_cancel_handling.py b/tests/server/test_cancel_handling.py
new file mode 100644
index 000000000..fb8c955d4
--- /dev/null
+++ b/tests/server/test_cancel_handling.py
@@ -0,0 +1,138 @@
+"""Test that cancelled requests don't cause double responses."""
+
+import asyncio
+from unittest.mock import MagicMock
+
+import pytest
+
+import mcp.types as types
+from mcp.server.lowlevel.server import Server
+from mcp.types import PingRequest
+
+
+# Shared mock class
+class MockRequestResponder:
+    def __init__(self):
+        self.request_id = "test-123"
+        self._responded = False
+        self.request_meta = {}
+        self.message_metadata = None
+
+    async def send(self, response):
+        if self._responded:
+            raise AssertionError(f"Request {self.request_id} already responded to")
+        self._responded = True
+
+    async def respond(self, response):
+        await self.send(response)
+
+    def cancel(self):
+        """Simulate the cancel() method sending an error response."""
+        asyncio.create_task(self.send(types.ErrorData(code=-32800, message="Request cancelled")))
+
+
+@pytest.mark.anyio
+async def test_cancelled_request_no_double_response():
+    """Verify server handles cancelled requests without double response."""
+
+    # Create a server instance
+    server = Server("test-server")
+
+    # Track if multiple responses are attempted
+    response_count = 0
+
+    # Override the send method to track calls
+    mock_message = MockRequestResponder()
+    original_send = mock_message.send
+
+    async def tracked_send(response):
+        nonlocal response_count
+        response_count += 1
+        await original_send(response)
+
+    mock_message.send = tracked_send
+
+    # Create a slow handler that will be cancelled
+    async def slow_handler(req):
+        await asyncio.sleep(10)
+        return types.ServerResult(types.EmptyResult())
+
+    # Use PingRequest as it's a valid request type
+    server.request_handlers[types.PingRequest] = slow_handler
+
+    # Create mock message and session
+    mock_req = PingRequest(method="ping")
+    mock_session = MagicMock()
+    mock_context = None
+
+    # Start the request
+    handle_task = asyncio.create_task(
+        server._handle_request(mock_message, mock_req, mock_session, mock_context, raise_exceptions=False)  # type: ignore
+    )
+
+    # Give it time to start
+    await asyncio.sleep(0.1)
+
+    # Simulate cancellation
+    mock_message.cancel()
+    handle_task.cancel()
+
+    # Wait for cancellation to propagate
+    try:
+        await handle_task
+    except asyncio.CancelledError:
+        pass
+
+    # Give time for any duplicate response attempts
+    await asyncio.sleep(0.1)
+
+    # Should only have one response (from cancel())
+    assert response_count == 1, f"Expected 1 response, got {response_count}"
+
+
+@pytest.mark.anyio
+async def test_server_remains_functional_after_cancel():
+    """Verify server can handle new requests after a cancellation."""
+
+    server = Server("test-server")
+
+    # Add handlers
+    async def slow_handler(req):
+        await asyncio.sleep(5)
+        return types.ServerResult(types.EmptyResult())
+
+    async def fast_handler(req):
+        return types.ServerResult(types.EmptyResult())
+
+    # Override ping handler for our test
+    server.request_handlers[types.PingRequest] = slow_handler
+
+    # First request (will be cancelled)
+    mock_message1 = MockRequestResponder()
+    mock_req1 = PingRequest(method="ping")
+
+    handle_task = asyncio.create_task(
+        server._handle_request(mock_message1, mock_req1, MagicMock(), None, raise_exceptions=False)  # type: ignore
+    )
+
+    await asyncio.sleep(0.1)
+    mock_message1.cancel()
+    handle_task.cancel()
+
+    try:
+        await handle_task
+    except asyncio.CancelledError:
+        pass
+
+    # Change handler to fast one
+    server.request_handlers[types.PingRequest] = fast_handler
+
+    # Second request (should work normally)
+    mock_message2 = MockRequestResponder()
+    mock_req2 = PingRequest(method="ping")
+
+    # This should complete successfully
+    await server._handle_request(mock_message2, mock_req2, MagicMock(), None, raise_exceptions=False)  # type: ignore
+
+    # Server handled the second request successfully
+    assert mock_message2._responded