diff --git a/README.md b/README.md
index 4fe663a..f5a7987 100644
--- a/README.md
+++ b/README.md
@@ -127,6 +127,7 @@ pymcuprog supports:
 * EDBG - on-board debugger on Xplained Pro/Ultra
 * mEDBG - on-board debugger on Xplained Mini/Nano
 * JTAGICE3 (firmware version 3.0 or newer)
+* Serial (TTY/COM) and RFC2217 compatible devices (serialupdi)
 
 Although not all functionality is provided on all debuggers/boards.  See device support section below.
 
diff --git a/pymcuprog/serialupdi/physical.py b/pymcuprog/serialupdi/physical.py
index 4e6a9ed..7b4dae1 100644
--- a/pymcuprog/serialupdi/physical.py
+++ b/pymcuprog/serialupdi/physical.py
@@ -4,6 +4,7 @@
 import time
 from logging import getLogger
 import serial
+import serial.rfc2217
 from serial.serialutil import SerialException
 
 from . import constants
@@ -48,6 +49,20 @@ def __init__(self, port, baud=DEFAULT_SERIALUPDI_BAUD, timeout=None):
         # send an initial break as handshake
         self.send([constants.UPDI_BREAK])
 
+    def _open_serial(self, port, *args, **kwargs):
+        """
+        Open a serial device (tty/com or rfc2217) based on the provided port type
+
+        :param port: Serial port name to connect to.
+        :param \**args: Additional arguments passed to Serial class.
+        :param \**args: Additional keyword arguments passed to Serial class.
+        """
+
+        if port.startswith("rfc2217://"):
+            return serial.rfc2217.Serial(port, *args, **kwargs)
+        else:
+            return serial.Serial(port, *args, **kwargs)
+
     def initialise_serial(self, port, baud, timeout):
         """
         Standard serial port initialisation
@@ -62,7 +77,7 @@ def initialise_serial(self, port, baud, timeout):
         """
         self.logger.info("Opening port '%s' at %d baud (timeout %.01fs)", port, baud, timeout)
         try:
-            self.ser = serial.Serial(port, baud, parity=serial.PARITY_EVEN, timeout=timeout, stopbits=serial.STOPBITS_TWO)
+            self.ser = self._open_serial(port, baud, parity=serial.PARITY_EVEN, timeout=timeout, stopbits=serial.STOPBITS_TWO)
         except SerialException:
             self.logger.error("Unable to open serial port '%s'", port)
             raise
@@ -90,7 +105,7 @@ def send_double_break(self):
         # At 300 bauds, the break character will pull the line low for 30ms
         # Which is slightly above the recommended 24.6ms
         self.ser.close()
-        temporary_serial = serial.Serial(self.port, 300, parity=serial.PARITY_EVEN, timeout=self.timeout,
+        temporary_serial = self._open_serial(self.port, 300, parity=serial.PARITY_EVEN, timeout=self.timeout,
                                          stopbits=serial.STOPBITS_ONE)
 
         # Send two break characters, with 1 stop bit in between