diff --git a/.github/workflows/ci.yaml b/.github/workflows/ci.yaml
index f27d2273..bffb576f 100644
--- a/.github/workflows/ci.yaml
+++ b/.github/workflows/ci.yaml
@@ -10,7 +10,7 @@ jobs:
     strategy:
       fail-fast: false
       matrix:
-        node: [14, 16, 18, 20]
+        node: [14, 16, 18, 20, 22]
     steps:
       - uses: actions/checkout@v4
       - uses: actions/setup-node@v4
diff --git a/system-test/system_test.sh b/system-test/system_test.sh
index c29f718c..2032ec80 100755
--- a/system-test/system_test.sh
+++ b/system-test/system_test.sh
@@ -14,7 +14,7 @@ cd $(dirname $0)
 # official releases. https://nodejs.org/en/about/releases/
 if [[ -z "$BINARY_HOST" ]]; then
   ADDITIONAL_PACKAGES="python3 g++ make"
-  NODE_VERSIONS=(14 16 18 20)
+  NODE_VERSIONS=(14 16 18 20 22)
 else
   # Tested versions for pre-built binaries are limited based on
   # what node-pre-gyp can specify as its target version.
diff --git a/system-test/test.sh b/system-test/test.sh
index 9c632f32..5c23b0cb 100755
--- a/system-test/test.sh
+++ b/system-test/test.sh
@@ -55,17 +55,31 @@ if [[ "$VERIFY_TIME_LINE_NUMBERS" != "true" ]]; then
   npm run compile
 fi
 
+NODE_VERSION=$(node -v | cut -d. -f1 | tr -d 'v')
 node -v
 node --trace-warnings "$BENCHPATH" 10 $VERIFY_TIME_LINE_NUMBERS
 
 if [[ "$VERIFY_TIME_LINE_NUMBERS" == "true" ]]; then
-  pprof -lines -top -nodecount=2 time.pb.gz | tee $tty | \
-      grep "busyLoop.*src/busybench.js:[2-3][08-9]"
-  pprof -filefunctions -top -nodecount=2 heap.pb.gz | tee $tty | \
-      grep "busyLoop.*src/busybench.js"
+  output=$(pprof -lines -top -nodecount=2 time.pb.gz | tee $tty)
+
+  # Due to V8 changes in Node 21, the line numbers are different.
+  # It also emits "anonymous" and "idle" statuses in the output.
+  # E.G: 1877ms 74.93% 74.93%     1878ms 74.97%  (anonymous) file:/tmp/tmp.xyz/busybench/src/busybench.js:34
+  if [ "$NODE_VERSION" -ge 21 ]; then
+    grep "anonymous.*busybench.js:3[0-9]" <<< "$output"
+  else
+    grep "busyLoop.*src/busybench.js:[23][0-9]" <<< "$output"
+  fi
+
+  heap_output=$(pprof -filefunctions -top -nodecount=2 heap.pb.gz | tee $tty)
+  grep "busyLoop.*src/busybench.js" <<< "$heap_output"
 else
-  pprof -filefunctions -top -nodecount=2 time.pb.gz | tee $tty | \
-      grep "busyLoop.*src/busybench.ts"
+  output=$(pprof -filefunctions -top -nodecount=2 time.pb.gz | tee $tty)
+  if [ "$NODE_VERSION" -ge 21 ]; then
+    grep "anonymous.*busybench.js" <<< "$output"
+  else
+    grep "busyLoop.*src/busybench.ts" <<< "$output"
+  fi
   pprof -filefunctions -top -nodecount=2 heap.pb.gz | tee $tty | \
       grep "busyLoop.*src/busybench.ts"
 fi