pharmacology of mephedrone (4mmc)

[zelixir25]

I don't know if this is posted or linked anywhere else but here is a study that shows mephedrone increasing both serotonin and dopamine in the brain in ways that are somewhat similar to MDMA. This could be useful when establishing risk of 4mmc combined with other serotonergic drugs when there are no studies available for that combination specifically. The final paragraph states:

In conclusion, the present data demonstrate for the first time that acute administration of mephedrone induces a rapid release of both 5-HT and DA in the NAcc of awake rats and this effect is accompanied by a short-lasting increase in locomotor activity. These results support the notion that mephedrone resembles the key neurochemical and functional properties of MDMA, confirming the similarities between mephedrone and MDMA effects reported by drug users. In addition, mephedrone-induced release and rapid elimination of DA in the NAcc were similar to the effect of amphetamine given at a dose relevant to its addictive properties. However, further studies are needed to elucidate the detailed mechanisms behind the reported risk of a compulsive binge intake of mephedrone and the risk for tolerance development.

Kehr, J., Ichinose, F., Yoshitake, S., Goiny, M., Sievertsson, T., Nyberg, F., & Yoshitake, T. (2011). Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5‐HT levels in nucleus accumbens of awake rats. British journal of pharmacology, 164(8), 1949-1958.