diff --git a/.changeset/three-parents-argue.md b/.changeset/three-parents-argue.md
new file mode 100644
index 00000000000..95517262fb9
--- /dev/null
+++ b/.changeset/three-parents-argue.md
@@ -0,0 +1,5 @@
+---
+'openzeppelin-solidity': patch
+---
+
+Add `_reentrancyGuardStorageSlot()` to `ReentrancyGuardTransient` as a `pure virtual` function to allow slot overrides for diamond-compatible modular usage. Related to #5681.
diff --git a/contracts/utils/ReentrancyGuardTransient.sol b/contracts/utils/ReentrancyGuardTransient.sol
index a1318c86f3c..9863b333f16 100644
--- a/contracts/utils/ReentrancyGuardTransient.sol
+++ b/contracts/utils/ReentrancyGuardTransient.sol
@@ -44,11 +44,11 @@ abstract contract ReentrancyGuardTransient {
         }
 
         // Any calls to nonReentrant after this point will fail
-        REENTRANCY_GUARD_STORAGE.asBoolean().tstore(true);
+        _reentrancyGuardStorageSlot().asBoolean().tstore(true);
     }
 
     function _nonReentrantAfter() private {
-        REENTRANCY_GUARD_STORAGE.asBoolean().tstore(false);
+        _reentrancyGuardStorageSlot().asBoolean().tstore(false);
     }
 
     /**
@@ -56,6 +56,10 @@ abstract contract ReentrancyGuardTransient {
      * `nonReentrant` function in the call stack.
      */
     function _reentrancyGuardEntered() internal view returns (bool) {
-        return REENTRANCY_GUARD_STORAGE.asBoolean().tload();
+        return _reentrancyGuardStorageSlot().asBoolean().tload();
+    }
+
+    function _reentrancyGuardStorageSlot() internal pure virtual returns (bytes32) {
+        return REENTRANCY_GUARD_STORAGE;
     }
 }