diff --git a/.github/workflows/Test.yml b/.github/workflows/Test.yml
index f604816e..929fc4e2 100644
--- a/.github/workflows/Test.yml
+++ b/.github/workflows/Test.yml
@@ -18,7 +18,7 @@ jobs:
     strategy:
       fail-fast: false
       matrix:
-        version: ['1.10', '1.11', '1.12-nightly'] # nightly
+        version: ['1.10', '1.11', '1.12-nightly', 'nightly']
         os: [ubuntu-latest, macOS-latest, windows-latest]
         arch: [x64]
         llvm_args: ['']
diff --git a/src/jlgen.jl b/src/jlgen.jl
index 7982fcbb..f98780f8 100644
--- a/src/jlgen.jl
+++ b/src/jlgen.jl
@@ -698,6 +698,26 @@ function compile_method_instance(@nospecialize(job::CompilerJob))
         cache_gbl = nothing
     end
 
+    if VERSION >= v"1.13.0-DEV.623"
+        # Since Julia 1.13, the caller is responsible for initializing global variables that
+        # point to global values or bindings with their address in memory.
+        num_gvars = Ref{Csize_t}(0)
+        @ccall jl_get_llvm_gvs(native_code::Ptr{Cvoid}, num_gvars::Ptr{Csize_t},
+                               C_NULL::Ptr{Cvoid})::Nothing
+        gvs = Vector{Ptr{LLVM.API.LLVMOpaqueValue}}(undef, num_gvars[])
+        @ccall jl_get_llvm_gvs(native_code::Ptr{Cvoid}, num_gvars::Ptr{Csize_t},
+                               gvs::Ptr{LLVM.API.LLVMOpaqueValue})::Nothing
+        inits = Vector{Ptr{Cvoid}}(undef, num_gvars[])
+        @ccall jl_get_llvm_gv_inits(native_code::Ptr{Cvoid}, num_gvars::Ptr{Csize_t},
+                                    inits::Ptr{Cvoid})::Nothing
+
+        for (gv_ref, init) in zip(gvs, inits)
+            gv = GlobalVariable(gv_ref)
+            val = const_inttoptr(ConstantInt(Int64(init)), LLVM.PointerType())
+            initializer!(gv, val)
+        end
+    end
+
     if VERSION >= v"1.12.0-DEV.1703"
         # on sufficiently recent versions of Julia, we can query the MIs compiled.
         # this is required after the move to `invokce(::CodeInstance)`, because our
diff --git a/src/spirv.jl b/src/spirv.jl
index 30461f1d..2015125d 100644
--- a/src/spirv.jl
+++ b/src/spirv.jl
@@ -51,8 +51,8 @@ end
 llvm_machine(::SPIRVCompilerTarget) = nothing
 
 llvm_datalayout(::SPIRVCompilerTarget) = Int===Int64 ?
-    "e-i64:64-v16:16-v24:32-v32:32-v48:64-v96:128-v192:256-v256:256-v512:512-v1024:1024" :
-    "e-p:32:32-i64:64-v16:16-v24:32-v32:32-v48:64-v96:128-v192:256-v256:256-v512:512-v1024:1024"
+    "e-i64:64-v16:16-v24:32-v32:32-v48:64-v96:128-v192:256-v256:256-v512:512-v1024:1024-G1" :
+    "e-p:32:32-i64:64-v16:16-v24:32-v32:32-v48:64-v96:128-v192:256-v256:256-v512:512-v1024:1024-G1"
 
 
 ## job
diff --git a/test/native.jl b/test/native.jl
index 19a6297c..18217613 100644
--- a/test/native.jl
+++ b/test/native.jl
@@ -273,7 +273,9 @@ end
     @test !occursin("%safepoint", ir)
 
     ir = sprint(io->Native.code_llvm(io, identity, Tuple{Nothing}; entry_safepoint=true, optimize=false, dump_module=true))
-    @test occursin("%safepoint", ir)
+    @test occursin("%safepoint", ir) broken=(VERSION >= v"1.13.0-DEV.533")
+    # XXX: broken by JuliaLang/julia#57010,
+    #      see https://github.com/JuliaLang/julia/pull/57010/files#r2079576894
 end
 
 @testset "always_inline" begin