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1 |
| -# psborrow2 |
| 1 | +# psborrow2 <img src="./inst/img/psborrow2_hex.png" align="right" width="120" /> |
| 2 | + |
| 3 | +<!-- badges: start --> |
| 4 | + |
| 5 | +[](https://github.com/Genentech/psborrow2) |
| 6 | +[](https://www.tidyverse.org/lifecycle/#experimental) |
| 8 | + |
| 9 | +<!-- badges: end --> |
2 | 10 |
|
3 | 11 | ## Overview
|
4 | 12 |
|
5 |
| -The `psborrow2` package exists to provide an efficient framework for users to |
6 |
| -conduct Bayesian Dynamic Borrowing (BDB) analyses (for more information on BDB, |
7 |
| -see Ibrahim et al., 2000; Hobbs et al., 2012; Schmidli et al., 2014; |
8 |
| -Lewis, et al., 2019). |
| 13 | +`psborrow2` provides an efficient framework for users to |
| 14 | +conduct Bayesian Dynamic Borrowing (BDB) analyses and other |
| 15 | +innovative analytical designs.[^1] [^2] |
| 16 | +`psborrow2` has two main objectives: |
| 17 | + |
| 18 | +1. **Facilitate BDB analyses**. `psborrow2` has a user-friendly interface for |
| 19 | + conducting BDB analyses that handles the computationally-difficult MCMC sampling |
| 20 | + on behalf of the user. |
9 | 21 |
|
10 |
| -`psborrow2` has two main goals: First, facilitate simulation studies that |
11 |
| -compare different borrowing parameters (e.g. full borrowing, no borrowing, BDB) |
12 |
| -and other trial and BDB characteristics (e.g. sample size, covariates) |
13 |
| -in a unified way; and second, provide a user-friendly interface for applying |
14 |
| -BDB on the study results that handles the MCMC sampling on behalf of the user. |
| 22 | +2. **Facilitate simulation studies of BDB**. `psborrow2` includes a |
| 23 | + framework to compare different trial and BDB characteristics in a unified way |
| 24 | + in simulation studies to inform trial design. |
15 | 25 |
|
16 |
| -`psborrow2` is the successor of |
17 |
| -[`psborrow`](https://github.com/Genentech/psborrow). Major updates to |
18 |
| -`psborrow2` include: |
| 26 | +## Background |
19 | 27 |
|
20 |
| -* New MCMC software (STAN) |
21 |
| -* New user interface |
22 |
| -* Additional functionality |
| 28 | +`psborrow2` is the successor to |
| 29 | +[`psborrow`](https://github.com/Genentech/psborrow). `psborrow` is still freely |
| 30 | +available on [`CRAN`](https://cran.r-project.org/package=psborrow) with the |
| 31 | +same validated functionality; however, the package is not actively developed. |
| 32 | +Major updates in `psborrow2` include: |
| 33 | + |
| 34 | +- New, more flexible user interface |
| 35 | +- New MCMC software (STAN) |
| 36 | +- Expanded functionality |
| 37 | + |
| 38 | +The name `psborrow` combines propensity scoring (`ps`) and Bayesian dynamic |
| 39 | +`borrow`ing. As the name implies, this package can be used to combine dynamic |
| 40 | +borrowing and propensity-score adjustment/weighting methods. |
23 | 41 |
|
24 | 42 | ## Installation
|
25 | 43 |
|
26 |
| -`psborrow2` is currently under development and should therefore be used with |
27 |
| -caution. You can install the development version via: |
| 44 | +You can install the latest version of `psborrow2` with: |
28 | 45 |
|
29 | 46 | ```r
|
30 | 47 | remotes::install_github("Genentech/psborrow2")
|
31 | 48 | ```
|
32 | 49 |
|
33 |
| -Please note that this package requires [`cmdstanr`](https://mc-stan.org/cmdstanr/) |
34 |
| -to be installed. |
| 50 | +Please note that this package requires [`cmdstanr`](https://mc-stan.org/cmdstanr/). |
| 51 | + |
| 52 | +## Vignettes |
| 53 | + |
| 54 | +To learn how to use the `psborrow2` R package, refer to the package vignettes: |
| 55 | + |
| 56 | +```r |
| 57 | +browseVignettes("psborrow2") |
| 58 | +``` |
| 59 | + |
| 60 | +## Bibliography |
| 61 | + |
| 62 | +[^1]: |
| 63 | + Lewis CJ, Sarkar S, Zhu J, Carlin BP. Borrowing from historical control data |
| 64 | + in cancer drug development: a cautionary tale and practical guidelines. |
| 65 | + Statistics in biopharmaceutical research. 2019 Jan 2;11(1):67-78. |
| 66 | + |
| 67 | +[^2]: |
| 68 | + Viele K, Berry S, Neuenschwander B, Amzal B, Chen F, Enas N, Hobbs B, |
| 69 | + Ibrahim JG, Kinnersley N, Lindborg S, Micallef S. Use of historical control |
| 70 | + data for assessing treatment effects in clinical trials. Pharmaceutical |
| 71 | + statistics. 2014 Jan;13(1):41-54. |
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