diff --git a/CMakeLists.txt b/CMakeLists.txt
index 58dddccb..d7dcd51c 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -45,6 +45,7 @@ option(ASTCENC_ISA_NONE "Enable astcenc builds for no SIMD")
 option(ASTCENC_ISA_NATIVE "Enable astcenc builds for native SIMD")
 option(ASTCENC_DECOMPRESSOR "Enable astcenc builds for decompression only")
 option(ASTCENC_SHAREDLIB "Enable astcenc builds with core library shared objects")
+option(ASTCENC_BIG_ENDIAN "Enable astcenc big-endian support")
 option(ASTCENC_DIAGNOSTICS "Enable astcenc builds with diagnostic trace")
 option(ASTCENC_ASAN "Enable astcenc builds with address sanitizer")
 option(ASTCENC_UBSAN "Enable astcenc builds with undefined behavior sanitizer")
@@ -137,6 +138,9 @@ if("${CMAKE_SYSTEM_NAME}" STREQUAL "Darwin")
     printopt("Universal bin      " ${ASTCENC_UNIVERSAL_BUILD})
 endif()
 printopt("Invariance         " ${ASTCENC_INVARIANCE})
+if(${ASTCENC_BIG_ENDIAN})
+    printopt("Big endian         " ${ASTCENC_BIG_ENDIAN})
+endif()
 printopt("Shared libs        " ${ASTCENC_SHAREDLIB})
 printopt("Decompressor       " ${ASTCENC_DECOMPRESSOR})
 message(STATUS "Developer options")
diff --git a/Docs/Building-BE.md b/Docs/Building-BE.md
index fad9cf33..8aad06ae 100644
--- a/Docs/Building-BE.md
+++ b/Docs/Building-BE.md
@@ -9,7 +9,7 @@ distributions still support BE platforms.
 Even though Arm64 can run in a BE mode, it's now very rare in practice. It's no
 longer supported out of the box in the latest Arm upstream compiler releases,
 and getting hold of a sysroot is increasingly difficult. To test BE builds, I
-therefore cross-compile Linux builds for MIPS64 and use `qemu-user` to run
+therefore cross-compile Linux builds for PPC64 and use `qemu-user` to run
 them. This doesn't use a real sysroot, and so everything must be compiled with
 `-static` linkage.
 
@@ -19,15 +19,16 @@ Install the following host software:
 
 ```bash
 # Compiler
-sudo apt-get install g++-mips64-linux-gnuabi64
+sudo apt-get install g++-powerpc64-linux-gnu
 
 # Multi-arch libraries
-sudo apt-get install g++-multilib-mips64-linux-gnuabi64
+sudo apt-get install g++-multilib-powerpc64-linux-gnu
 
 # QEMU
-sudo apt-get install qemu-user-static
+sudo apt-get install qemu-user-static qemu-user-binfmt binfmt-support
 sudo mkdir /etc/qemu-binfmt
-sudo ln -s /usr/mips64-linux-gnuabi64 /etc/qemu-binfmt/mips64
+sudo ln -s /usr/powerpc64-linux-gnu /etc/qemu-binfmt/ppc64
+sudo update-binfmts --import qemu-ppc64
 ```
 
 ## CMake toolchain file
@@ -41,19 +42,21 @@ file in the root of the project, with the following content:
 set(CMAKE_SYSTEM_NAME Linux)
 
 # Cross-compilers for C and C++
-set(CMAKE_C_COMPILER mips64-linux-gnuabi64-gcc)
-set(CMAKE_CXX_COMPILER mips64-linux-gnuabi64-g++)
+set(CMAKE_C_COMPILER   powerpc64-linux-gnu-gcc)
+set(CMAKE_CXX_COMPILER powerpc64-linux-gnu-g++)
 
 # Compiler environment
-set(CMAKE_FIND_ROOT_PATH /usr/mips64-linux-gnuabi64)
+set(CMAKE_FIND_ROOT_PATH /usr/powerpc64-linux-gnu)
 
-# Default compiler and linker flags to use
 set(CMAKE_C_FLAGS_INIT -static)
 set(CMAKE_CXX_FLAGS_INIT -static)
 set(CMAKE_EXE_LINKER_FLAGS_INIT -static)
 set(CMAKE_SHARED_LINKER_FLAGS_INIT -static)
 set(CMAKE_MODULE_LINKER_FLAGS_INIT -static)
 
+# Build options
+set(ASTCENC_BIG_ENDIAN ON)
+
 # Never match host tools
 set(CMAKE_FIND_ROOT_PATH_MODE_PROGRAM NEVER)
 
@@ -78,8 +81,17 @@ cmake -DCMAKE_BUILD_TYPE=Release -DCMAKE_INSTALL_PREFIX=../ -DASTCENC_ISA_NONE=O
 The cross-compiled `astcenc` binary runs as normal, and can access host files,
 but must run through QEMU to do the instruction set translation.
 
+If the binfmt setup performed earlier was successful you can just run the
+binary as if it were a native binary:
+
+```
+./bin/astcenc-none ...
+```
+
+... but otherwise you can run it manually using QEMU as a wrapper:
+
 ```
-qemu-mips64 ./bin/astcenc-none ...
+qemu-ppc64 ./bin/astcenc-none ...
 ```
 
 - - -
diff --git a/Source/UnitTest/cmake_core.cmake b/Source/UnitTest/cmake_core.cmake
index 71c99dc2..49c5a45c 100644
--- a/Source/UnitTest/cmake_core.cmake
+++ b/Source/UnitTest/cmake_core.cmake
@@ -85,6 +85,12 @@ if(${ASTCENC_ISA_SIMD} MATCHES "none")
             ASTCENC_POPCNT=0
             ASTCENC_F16C=0)
 
+    if(${ASTCENC_BIG_ENDIAN})
+        target_compile_definitions(${ASTCENC_TEST}
+            PRIVATE
+                ASTCENC_BIG_ENDIAN=1)
+    endif()
+
 elseif(${ASTCENC_ISA_SIMD} MATCHES "neon")
     target_compile_definitions(${ASTCENC_TEST}
         PRIVATE
diff --git a/Source/UnitTest/test_simd.cpp b/Source/UnitTest/test_simd.cpp
index c49c23fd..df828683 100644
--- a/Source/UnitTest/test_simd.cpp
+++ b/Source/UnitTest/test_simd.cpp
@@ -2015,10 +2015,17 @@ TEST(vint4, interleave_rgba8)
 
 	vint4 result = interleave_rgba8(r, g, b, a);
 
+#if !defined(ASTCENC_BIG_ENDIAN)
 	EXPECT_EQ(result.lane<0>(), 0x04030201);
 	EXPECT_EQ(result.lane<1>(), 0x14131211);
 	EXPECT_EQ(result.lane<2>(), 0x24232221);
 	EXPECT_EQ(result.lane<3>(), 0x34333231);
+#else
+	EXPECT_EQ(result.lane<0>(), 0x01020304);
+	EXPECT_EQ(result.lane<1>(), 0x11121314);
+	EXPECT_EQ(result.lane<2>(), 0x21222324);
+	EXPECT_EQ(result.lane<3>(), 0x31323334);
+#endif
 }
 
 # if ASTCENC_SIMD_WIDTH == 8
diff --git a/Source/astcenc_vecmathlib_none_4.h b/Source/astcenc_vecmathlib_none_4.h
index f25c92be..57ebe84f 100644
--- a/Source/astcenc_vecmathlib_none_4.h
+++ b/Source/astcenc_vecmathlib_none_4.h
@@ -694,7 +694,11 @@ ASTCENC_SIMD_INLINE void pack_and_store_low_bytes(vint4 a, uint8_t* p)
 	int b2 = a.m[2] & 0xFF;
 	int b3 = a.m[3] & 0xFF;
 
+#if !defined(ASTCENC_BIG_ENDIAN)
 	int b = b0 | (b1 << 8) | (b2 << 16) | (b3 << 24);
+#else
+	int b = b3 | (b2 << 8) | (b1 << 16) | (b0 << 24);
+#endif
 	a = vint4(b, 0, 0, 0);
 	store_nbytes(a, p);
 }
@@ -1171,7 +1175,11 @@ ASTCENC_SIMD_INLINE vint4 vtable_lookup_32bit(
  */
 ASTCENC_SIMD_INLINE vint4 interleave_rgba8(vint4 r, vint4 g, vint4 b, vint4 a)
 {
+#if !defined(ASTCENC_BIG_ENDIAN)
 	return r + lsl<8>(g) + lsl<16>(b) + lsl<24>(a);
+#else
+	return a + lsl<8>(b) + lsl<16>(g) + lsl<24>(r);
+#endif
 }
 
 /**
diff --git a/Source/cmake_core.cmake b/Source/cmake_core.cmake
index 59772023..7b3e47c9 100644
--- a/Source/cmake_core.cmake
+++ b/Source/cmake_core.cmake
@@ -284,6 +284,12 @@ macro(astcenc_set_properties ASTCENC_TARGET_NAME ASTCENC_VENEER_TYPE)
                 ASTCENC_POPCNT=0
                 ASTCENC_F16C=0)
 
+        if(${ASTCENC_BIG_ENDIAN})
+            target_compile_definitions(${ASTCENC_TARGET_NAME}
+                PRIVATE
+                    ASTCENC_BIG_ENDIAN=1)
+        endif()
+
     elseif(${ASTCENC_ISA_SIMD} MATCHES "neon")
         target_compile_definitions(${ASTCENC_TARGET_NAME}
             PRIVATE