diff --git a/.gitignore b/.gitignore
index e68c2e4f72..0deb0a2358 100644
--- a/.gitignore
+++ b/.gitignore
@@ -9,15 +9,9 @@ tests/cpp/build_xcode/*
 tests/cpp/Testing/*
 
 doc-venv/*
-doc/*
 fonts/*
 images/*
 stylesheets/*
-documentation/_build/*
-documentation/_exhale_cpp_api/*
-documentation/_exhale_matlab_api/*
-documentation/_doxyoutput_amici_cpp/*
-documentation/_doxyoutput_amici_matlab/*
 sed-ml/*
 
 models/*
diff --git a/doc/.gitignore b/doc/.gitignore
new file mode 100644
index 0000000000..11c4ae4a9e
--- /dev/null
+++ b/doc/.gitignore
@@ -0,0 +1,7 @@
+_build/
+_doxyoutput_amici_cpp/
+_doxyoutput_amici_matlab/
+_exhale_cpp_api/
+_exhale_matlab_api/
+examples/example_presimulation/model_presimulation/
+generated/
diff --git a/doc/PYTHON.rst b/doc/PYTHON.rst
index cba7b08ee7..1c16614638 100644
--- a/doc/PYTHON.rst
+++ b/doc/PYTHON.rst
@@ -8,5 +8,6 @@ Python interface
    Installation <python_installation>
    Examples <python_examples>
    Usage <python_interface>
+   Caveats <python_caveats>
    FAQ <python_faq>
    API reference <python_modules>
diff --git a/doc/python_caveats.rst b/doc/python_caveats.rst
new file mode 100644
index 0000000000..e05571fb56
--- /dev/null
+++ b/doc/python_caveats.rst
@@ -0,0 +1,78 @@
+.. _python_caveats:
+
+=======
+Caveats
+=======
+
+This section lists some caveats that are important to be aware of when using
+AMICI.
+
+See also the `list of known bugs <https://github.com/AMICI-dev/AMICI/issues?q=is%3Aissue%20state%3Aopen%20label%3Abug>`__.
+
+Sensitivity analysis
+====================
+
+AMICI provides high-performance sensitivity analysis for a broad range of
+models. However, there are some limitations to be aware of:
+
+* Adjoint sensitivity analysis is not fully supported for models with
+  discontinuities (e.g. events).
+  See `this issue <https://github.com/AMICI-dev/AMICI/issues/18>`__.
+
+* Sensitivity analysis for DAE models with events is not supported.
+  See `this issue <https://github.com/AMICI-dev/AMICI/issues/2102>`__.
+
+* Sensitivities may be incorrect for models with cascading events, where
+  secondary events have a bolus.
+
+* Sensitivities w.r.t. event trigger parameters may be incorrect for models
+  with simultaneous events.
+
+When working with a new model, it is recommended to check the sensitivities
+against finite differences. This is demonstrated in the example notebooks.
+This applies in particular to models with special features such as
+events or to :term:`DAE` models.
+
+Steady states
+=============
+
+AMICI provides various ways for computing steady states and steady state
+sensitivities. However, there are some limitations to be aware of:
+
+* A steady state is defined as a state where the time-derivative of the
+  state variables is – and remains – zero. However, AMICI's steady state
+  computation will stop as soon as the state time-derivative is smaller than
+  the specified tolerance. This may lead to incorrect results
+  for models with discontinuities (e.g. events) if the state time-derivative
+  crosses the threshold before the discontinuity is reached.
+  In this case, specify some large last output time instead of infinity to
+  ensure that simulation does not stop prematurely.
+
+* Currently, events are not processed at all during pre-equilibration.
+  *This is subject to change in the future (See `here <https://github.com/AMICI-dev/AMICI/issues/2386>`__).*
+  If events influence the steady state, the steady state computation may not
+  yield the correct result.
+  If skipping events is indeed desired, make sure to future-proof your model
+  and include a switch in the event trigger to disable the event during
+  pre-equilibration.
+
+
+Discontinuities
+===============
+
+AMICI is generally able to handle discontinuities in the model, such as events
+or Boolean expressions. However, there are some limitations to be aware of:
+
+* Not all event triggers are fully supported by the currently employed root
+  finding algorithm. In particular, ``>`` and ``>=`` as well as ``<`` and
+  ``<=`` cannot be distinguished. Also complex logical expressions where
+  multiple operators are time-dependent may not be handled correctly.
+  See, for example, `this issue <https://github.com/AMICI-dev/AMICI/issues/2707>`__.
+
+* Discontinuities at the initial time point may not be fully supported.
+  See, for example, `this issue <https://github.com/AMICI-dev/AMICI/issues/2724>`__.
+
+Always check whether the simulation results are as expected.
+
+Also, note the points above regarding sensitivity analysis and steady state
+computation for models with discontinuities.